New SADLE takes its name from "New Skill and Development Learning Experience." New SADLE is a not-for-profit training and employment program for artisans who have had leprosy or polio, who have other disabilities, or who are socially disadvantaged. The organization offers free medical treatment to artisans and provides handicraft skills that can lead to financially sustainable jobs, important in a society where people with leprosy are often shunned and forced to beg. New SADLE encourages artisans to return to their homes, and provides rent and child allowances to enable integration into society. This helps break down the stigma and isolation associated with leprosy. Artisans receive free day-care and schooling up to grade 12 for their children. New SADLE runs a medical center, two mobile health clinics, a hospital and two homes for people who cannot work and who have no family.

New SADLE finds its origins in Sewa Kendra Leprosy Station, established in 1989 by a German organization seeking a cure to leprosy. The organization realized treatment was not enough, and started a rehabilitation program in 1991-in Kathmandu, Kalaiya and Pokhara for leprosy and polio victims. Since 1997 this has been known as New SADLE. Looking ahead to possible eradication of leprosy, in 2000 New SADLE's charter was expanded to include work with orphans, HIV-positive individuals and victims of conflict. New SADLE opened Lovely Angels English High School in 2005, which currently has 550 students. Schooling is free for children of New SADLE artisans, beneficiaries, staff and needy children.

Ten Thousand Villages purchases home decor textiles, personal accessory textiles and singing bowls from New SADLE. Ten Thousand Villages has purchased products from New SADLE since 2001.